10 21 2025

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Sentinel-Lymph-Node Biopsy Alone or with Lymphadenectomy in Cervical Cancer

A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus

Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency

Mass Administration of Azithromycin to Infants in Mali to Reduce Mortality

  Journal of  American Medical Association

Intra-Arterial Alteplase After Successful Endovascular Reperfusion in Acute Stroke

The PEARL Randomized Clinical Trial

Annals of Internal Medicine

Effectiveness of Recombinant Herpes Zoster Vaccine in the U.S. Medicare Population, 2018 to 2019, by Immunocompetence and Prior Receipt of Live Zoster Vaccine

 British Medical Journal

Sodium-glucose cotransporter-2 inhibitors and risk of autoimmune rheumatic diseases: population based cohort study

  Lancet

The global, regional, and national burden of cancer, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023

 JAMA oncology 

Pathogenic Variants, Family History, and Cumulative Risk of Breast Cancer in US Women

  Gastroenterology

Efficacy of ACupuncTure in Irritable bOwel syNdrome (ACTION): A Multicenter Randomized Controlled Trial

  Clinical Gastroenterology

Safety and Efficacy of Endoscopic Submucosal Dissection for Rectal Neoplasms Extending to the Dentate Line: A Systematic Review and Meta-analysis

  Clinical Infectious Diseases

Dolutegravir/Lamivudine for Maintenance of Virological Suppression in Persons With Historical Suspected or Confirmed Resistance to Lamivudine: Week 48 Results of a Single-Arm, Open-Label, Multicenter, Phase IIa Clinical Trial

  Journal of Clinical Rheumatology 

Knowledge and Behaviors in Reproductive Health Among Mexican Women With Autoimmune Rheumatic Diseases: Cross-sectional Study

  Circulation

Contemporary Burden of Cardiovascular Disease in Pregnancy: Insights From a Real-World Pregnancy Electronic Health Record Cohort

  Journals of the American College of Cardiology

Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women

 JAMA Cardiology

Efficacy and Tolerability of Finerenone According to the Use and Dosage of DiureticsA Prespecified Analysis of the FINEARTS-HF Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Evaluation of Aldosterone Suppression by Cinnarizine, a Putative Cav1.3 Inhibitor 

 Chest

The Association Between Mechanical Power Within the First 24 Hours and ICU Mortality in Mechanically Ventilated Adult Patients With Acute Hypoxemic Respiratory Failure

 The American Journal of Respiratory and Critical Care Medicine

One-Year Change in Quantitative Computed Tomography Is Associated with Meaningful Outcomes in Fibrotic Lung Disease

 Clinical Journal of American Society of Nephrology

The Association of Long COVID and CKD: Findings from the National Clinical Cohort Collaborative

 Kidney International reports

Effects of Combination Treatment on Renal Endothelial Function in Type 2 Diabetes Mellitus