EPISODE · May 20, 2026 · 20 MIN
1004-组织张力驱动巨噬细胞诱导的DNA损伤
from 聊聊Sci
这项研究揭示了组织张力、纤维化与癌症风险及病情进展之间的机械关联。研究表明，乳腺肿瘤的硬化会激活上皮细胞中的STAT3信号，进而释放趋化因子以招募巨噬细胞。这些被招募的细胞在压力环境下会发生脂质过氧化，产生能够扩散的脂醛，从而造成邻近上皮细胞的DNA损伤并积累基因突变。通过中和氧化磷脂或抑制相关信号通路，可以有效减轻这种由张力诱导的遗传损伤。该发现解释了为什么高乳腺密度和组织纤维化会增加患癌风险，并为癌症预防提供了新视角。References:Tissue tension fosters macrophage-driven lipid peroxidation-induced DNA damage前往小宇宙评论区与主播互动
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