101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis

JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base is independent and ad-free — no sponsors, no paywall. If an episode was worth your time, chip in and keep the papers audited and the original songs coming:❤️ Support monthly: https://buy.stripe.com/cNifZhclVebvagk2JDgEg01☕ One-time donation: https://donate.stripe.com/7sY4gz71B2sN3RWac5gEg00 More at basebybase.com On PaperCast Base by Base you'll discover the latest in genomics, functional genomics, structural genomics, and proteomics. Episode link: https://basebybase.com/episodes/jak2-inhibition-selects-ras-mutant-clones-in-myelofibrosis Chapters (00:00:14) - Papercast: The dynamic dance of cancer biology(00:01:56) - JEK-inhibitors: The precision of their targeting(00:07:19) - Ruxolitinib and the Ras mutation(00:12:52) - JAK2 inhibition in metastatic pancreatic cancer(00:17:00) - The oncogene overdose or paradoxical selection