1013-巨噬细胞对活细胞的亚微米级采样

这项研究揭示了巨噬细胞一种名为“类胞吐作用”的新型采样机制，使其能够从活细胞中直接获取物质。与传统的吞噬死细胞不同，这种过程依赖于细胞接触而非细胞凋亡，通过拉伸目标细胞膜形成含有细胞质的微小囊泡。研究人员利用高维流式细胞术发现，这些被摄取的物质进入了特定的非降解途径，有效避开了溶酶体的破坏。这种独特的处理方式能更持久地保存自我也抗原，并表现出更强地激活CD8 T细胞的能力。此外，通过干预SNX27蛋白可以改变抗原的运送路径，进而证实了该采样机制在维持免疫稳态和自我耐受中的核心作用。References:Fan A C, Thota R R, Serwas N, et al. Submicrometre sampling of living cells by macrophages[J]. Nature, 2026: 1-9.前往小宇宙评论区与主播互动

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