EPISODE · May 23, 2026 · 19 MIN
1020-p53在体细胞化学重编程中的守护作用
from 聊聊Sci
这项研究揭示了p53蛋白在人类体细胞化学重编程为多能干细胞（CiPSCs）过程中的核心保障作用。不同于其在传统转录因子诱导重编程（OSKM）中作为障碍的角色，p53对于化学重编程的效率和基因组稳定性至关重要。研究发现，通过小分子药物的协同作用，细胞能在维持p53表达的同时抑制其下游促凋亡因子p21，从而确保细胞在快速增殖的同时避免过度上皮-间充质转化（EMT）。此外，利用p53-BTG2轴的抗肿瘤特性，该方法能有效清除缺陷细胞，使生成的CiPSCs具有更少的基因突变。这一发现为开发更安全、受控的再生医学和细胞身份转化技术提供了重要的理论支持。References:Cheng L, Wang Y, Yang Z, et al. p53 safeguards chemical reprogramming of human somatic cells toward pluripotency[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1020-p53在体细胞化学重编程中的守护作用
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