EPISODE · May 26, 2026 · 26 MIN
1035-全基因组倍增通过沉默抗原提呈驱动免疫逃逸
from 聊聊Sci
这项研究深入探讨了全基因组倍增（WGD）如何通过免疫逃逸机制推动乳腺癌的发展。研究发现，倍增后的癌细胞会表现出抗原呈递功能受损，从而逃避CD8+ T细胞的攻击，使其在免疫功能正常的宿主体内快速生长。这种现象源于代谢水平的改变，尤其是琥珀酸含量的增加导致KDM6去甲基化酶活性下降。这一变化进一步引发了H3K27me3组蛋白修饰水平的升高，从而在表观遗传层面限制了免疫反应基因的表达。最后，研究表明PRC2抑制剂能够有效恢复抗原呈递功能，为治疗WGD+型癌症提供了潜在的临床策略。References:Foidart P, Li Z, Cai X, et al. Whole-genome doubling drives immune evasion by silencing antigen presentation[J]. Cancer cell, 2026.前往小宇宙评论区与主播互动
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1035-全基因组倍增通过沉默抗原提呈驱动免疫逃逸
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