EPISODE · May 29, 2026 · 22 MIN
1047-类器官模拟癌症转移生态位的进展
from 聊聊Sci
这篇综述探讨了利用人类诱导多能干细胞（hiPSC）衍生的类器官模型，来模拟实体瘤在大脑、肺、肝脏和骨骼等器官中的转移生态位。传统的啮齿动物实验因物种差异和通量限制，难以有效转化为临床疗法，而将类器官与癌细胞共同培养形成的“嵌合体（Chimeroids）”为研究肿瘤定植提供了新途径。文章详细介绍了如何通过集成基质、血管和免疫成分来增强模型的生理相关性，从而更精准地还原复杂的肿瘤微环境。这种具有扩展性的体外平台不仅支持大规模的遗传和药物筛选，还为发现新的治疗靶点提供了重要工具。虽然类器官在细胞成熟度和复杂性上仍面临挑战，但其在个性化医疗和药物研发领域展现出巨大的应用潜力。References:Baumann Z, Billy E, Scheidmann M C. Advancements in organoid models emulating metastatic niches[J]. Trends in Cancer, 2026.前往小宇宙评论区与主播互动
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1047-类器官模拟癌症转移生态位的进展
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