105. SS-31 Peptide and Other Supplements in the Context of Mitochondrial Dysfunction, The Mitophagy Stack More Powerful Than Urolithin A Alone, How Mitochondrial Dysfunction Creates Chronic Fatigue

In this episode, we explore the research behind SS-31 peptide and other supplements as possible groundbreaking interventions for mitochondrial dysfunction, shedding light on their mechanisms as detailed in the scientific literature. We delve into the concept of the mitophagy stack, presenting it as a superior alternative to "Urolithin a" alone, for enhancing the clearance of damaged mitochondria and rejuvenating cellular energy production. Furthermore, we unravel the complex relationship between mitochondrial dysfunction and chronic fatigue, elucidating how impaired energy production at the cellular level can lead to pervasive fatigue and compromised quality of life. Topics: Introduction to Mitochondrial Dysfunction Chronic illnesses and their relation to mitochondrial dysfunction Examples: Chronic Fatigue, Chronic Inflammatory Response Syndrome, Lyme Disease, Candida Overgrowth... Importance of understanding mitochondrial dysfunction on a large scale and biochemical level Understanding Mitochondrial Dysfunction Definition and general overview Underlying causes: Genetic mutations, environmental stressors, toxins, aging Biochemical pathways involved: Oxidative phosphorylation, reactive oxygen species (ROS) generation, calcium homeostasis, apoptosis Oxidative Phosphorylation and Dysfunction Role in ATP production Components: Electron Transport Chain (ETC) and ATP Synthase Dysfunctional aspects due to genetic mutations and aging Vicious cycle of mitochondrial DNA mutations, decreased ATP production, and increased ROS Factors Contributing to Mitochondrial Dysfunction Genetic mutations (mtDNA and nDNA) Aging and its impact on mtDNA Environmental toxins and stressors (e.g., psychological stress, radiation, biotoxins, toxicants, nutrient deficiency) Nuclear DNA alterations Mitophagy and Mitochondrial Biogenesis Importance of removing old and damaged mitochondria Role of urolithin a and its enhancement with EGCG in mitophagy Supporting biogenesis: PQQ, resveratrol, EGCG, anthocyanins, curcumin, glycyrrhizic acid, salidroside Supplements and Nutrients for Supporting Mitochondrial Function Clinical trials and effective supplements: L-carnitine, α-lipoic acid, CoQ10, NAD precursors, membrane phospholipids Peptide Therapy for Mitochondrial Dysfunction Introduction to SS-31 peptide Mechanism: Binding to cardiolipin for efficient oxidative phosphorylation Potential for stimulating mitochondrial biogenesis Conclusion and Reminder Only ever work with a medical professional. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!