EPISODE · May 30, 2026 · 16 MIN
1051-工程化CAR单核细胞协同清除纤维化并促进心脏再生
from 聊聊Sci
这项研究开发了一种名为多功能嵌合抗原受体单核细胞（pCAR-Mos）的创新细胞疗法，用于治疗心肌梗死及其引发的心力衰竭。研究人员通过基因工程手段，使单核细胞能够靶向识别成纤维细胞激活蛋白（FAP），从而清除导致心脏纤维化的有害成纤维细胞。同时，这些细胞被设计成能分泌Agrin蛋白，这种蛋白可以有效刺激心肌细胞再生并促进血管新生。实验证明，单核细胞比传统的巨噬细胞具有更强的心脏靶向性与组织渗透力，能更精准地募集到受损区域。研究结果显示，pCAR-Mos疗法显著缩小了小鼠的心梗面积并恢复了心脏泵血功能。这种双重功能的治疗策略为修复受损心肌和逆转心脏纤维化提供了极具潜力的临床应用前景。References:Wu Z, Zou X, Chen C, et al. Engineered CAR-monocytes coordinate fibrosis clearance and cardiac regeneration following myocardial infarction[J]. Cell Stem Cell, 2026.前往小宇宙评论区与主播互动
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1051-工程化CAR单核细胞协同清除纤维化并促进心脏再生
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