1053-慢性结肠炎时空转录组图谱

这项研究通过整合时空转录组学、单细胞测序和批量核糖核酸测序技术，构建了实验性慢性结肠炎的全面分子图谱。研究人员利用多种小鼠模型模拟人类炎症性肠病的演变过程，揭示了肠道内免疫、上皮和间质细胞群的动态重塑规律。分析发现，中性粒细胞的扩张与特定的炎症程序在小鼠和人类之间具有高度保守性，且上皮细胞在炎症期间会普遍增强抗原递呈功能。此外，该研究识别出三种在空间和时间上互不相同的炎症程序，并证实了三级淋巴结构在缺乏B细胞的情况下仍能形成。这些高分辨率数据为理解肠道炎症的起始与进展提供了新框架，有助于精准选择治疗靶点和优化临床策略。References:* Fransson J, Sorini C, Castillo F, et al. Spatiotemporal analysis reveals distinct inflammatory programs underlying chronic ...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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1053-慢性结肠炎时空转录组图谱

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