EPISODE · May 30, 2026 · 12 MIN
1055-成熟树突状细胞通过Notch2信号塑造T细胞微环境
from 聊聊Sci
这项研究揭示了淋巴结内成纤维网状细胞（FRC）分化的分子机制，重点阐述了Notch2 信号通路在其中的核心作用。研究发现，成熟树突状细胞（DC）通过提供 Jagged1 配体，诱导并维持了 Ccl19高表达型 T区网状细胞（TRC）的身份。这种细胞间的相互作用构建了淋巴结中心 T细胞区 的特化生态位，对 CD8+ T细胞 的聚集和记忆前体细胞的形成至关重要。通过对小鼠模型和人类淋巴结样本的对比分析，研究证实了这一基质-免疫细胞回路在进化上的保守性。如果缺失 Notch2 信号，FRC 将无法实现功能特化，进而破坏淋巴结的微环境隔离并损害长期免疫记忆的产生。References:Alouche N, Cannelle H, Favre S, et al. Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches[J]. Immunity, 2026.前往小宇宙评论区与主播互动
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1055-成熟树突状细胞通过Notch2信号塑造T细胞微环境
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