1059-TranscriptFormer：跨越十五亿年进化的生成式细胞图谱

这篇文章介绍了一种名为 TranscriptFormer 的创新性生成式单细胞基础模型，旨在解决跨物种比较细胞生物学的难题。该模型家族通过对涵盖 12 个物种、跨越 15 亿年进化史的 1.12 亿个细胞进行大规模预训练，成功捕捉了生命树中保守的基因表达规律。研究表明，该模型在细胞类型鉴定、疾病状态预测以及药物扰动模拟等任务中达到了顶尖性能，甚至能对未见过的物种进行零样本预测。此外，TranscriptFormer 展现出了惊人的涌现能力，能够自发识别发育轨迹和系统发育关系，并作为“虚拟仪器”通过提示词预测基因调控网络。这项研究证明了复杂的细胞转录组遵循可学习且可预测的进化模式，为利用人工智能驱动生物学发现奠定了基础。References:* Pearce J D, Simmonds S E, Mahmoudabadi G, et al. TranscriptFormer...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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