106: Akkermansia: The Metabolism Microbe Every Woman Should Know episode artwork

EPISODE · Apr 12, 2026 · 48 MIN

106: Akkermansia: The Metabolism Microbe Every Woman Should Know

from Hormones, Metabolism & You! · host Cassie Smith

What if everything you’ve been told about your metabolism is missing the most important piece? In this episode, I sit down with Dr. Colleen Cutcliffe to uncover the powerful and often overlooked connection between your gut microbiome, your hormones, and your metabolism. We dive into why so many women start experiencing stubborn weight changes, cravings, energy crashes, and insulin resistance, especially in perimenopause and menopause, and how the root cause may go far deeper than calories or willpower. I also ask the big questions you’ve probably wondered about but never had answered clearly. Is your gut actually acting like an endocrine organ? Why are most probiotics not created equal? And what is this “Akkermansia” strain everyone is starting to talk about and why does it matter so much for metabolism, GLP-1 signaling, and even longevity? We break down the science in a way that actually makes sense and connect it back to what’s happening in your body right now so you can finally see the full picture. Topics We Cover in This Episode:  Why your metabolism may feel completely different lately and what’s really driving it The hidden role your gut plays in hormone signaling and insulin response What most probiotics are missing and why that matters more than you think The surprising reason some people struggle with cravings, fullness, and energy How your microbiome shifts during perimenopause and menopause The connection between gut health, inflammation, and long-term disease risk Why “you are what you eat” is only part of the story What might actually be influencing longevity at the microbial level Share this episode with a friend who’s been struggling with the same symptoms, and make sure you’re subscribed! Resources & Links Connect with Dr. Colleen Cutcliffe📸 Pendulum Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/pendulumlifeco/  📸 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/drcolleencutcliffe/ 📲 Follow Dr. Cassie Smith & Modern Endocrine 💻 Website:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modern-endocrine.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  📸 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/modernendocrine_/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  🌟 Facebook:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/ModernEndocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  📽️ YouTube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/@modernendocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  🕹️ TikTok:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@modernendocrine?lang=en⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  📰 Newsletter:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://linktr.ee/modernendocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  ➡️ Disclaimer:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modernendocrineokc.com/disclaimer-6353⁠

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