EPISODE · May 31, 2026 · 23 MIN
1060-高效快动共价蛋白药物筛选系统
from 聊聊Sci
这项研究开发了一个高通量筛选平台，旨在解决共价蛋白药物普遍存在的反应速度慢以及在体内半衰期短的瓶颈。研究人员通过将酵母展示技术与化学修饰相结合，成功设计出能够快速且持久锁定目标的共价纳米抗体和激动剂。实验证明，新型共价蛋白如 IB101（针对 PD-L1）和 IB201（针对 IL-18Rα）展现出远超传统药物的结合动力学和抗肿瘤疗效。该系统不仅提升了药物在较低浓度下的靶向参与度，还显著增强了免疫细胞的活性。此外，这种策略在新冠病毒中和蛋白的设计上也表现出极强的通用性，为开发下一代高效共价生物治疗药物提供了全新路径。References:Fan Q, Mei J, Li T, et al. A high-throughput selection system for fast-acting covalent protein drugs[J]. Science, 2026: eadv3081.前往小宇宙评论区与主播互动
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1060-高效快动共价蛋白药物筛选系统
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