EPISODE · Jun 2, 2026 · 16 MIN
1067-脏器内在神经系统的谱系与发育机制
from 聊聊Sci
这篇文章通过对心脏、肺、胰腺和肠道的跨器官分析，揭示了器官内在神经系统（OINS）发育的双重逻辑。研究发现，神经嵴细胞的迁徙谱系预先决定了神经元的空间分布架构：源自肠道神经嵴的神经元呈弥漫性分布，而源自施万细胞前体（SCP）的神经元则集中在特定神经节。然而，神经元的分子身份主要受局部器官环境的指令性诱导，而非取决于其胚胎起源。通过体外共培养实验，研究者证实细胞外基质（ECM）信号在引导神经元分化和塑造器官特有转录特征中起核心作用。这一发现确立了器官如何主动构建其神经系统的基本范式，为理解身脑整合机制及相关疾病提供了科学依据。References:Hsu I U Y, Zhao J, Lin Y, et al. Lineage and organ signals sequentially build organ intrinsic nervous systems[J]. Nature, 2026: 1-9.前往小宇宙评论区与主播互动
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1067-脏器内在神经系统的谱系与发育机制
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