1068-皮层发育的细胞时空基因表达图谱

这份研究通过机器视觉和单细胞转录组学构建了一个跨物种的通用框架，系统性地比较了小鼠、人类及人类大脑类器官在皮层发育过程中的基因表达动态。研究发现，虽然神经元程序相对保守，但中间祖细胞（IPs）在人类进化过程中表现出显著的转录发散性，反映了皮层扩张的演化机制。通过这一框架，科学家识别出共享基因JUNB在不同物种间存在表达模式差异：它在人类中维持放射状胶质细胞（RG）的增殖，而在小鼠中则在神经元内表达。实验证明，上游调节因子IRF1在人类细胞中的特异性存在激活了JUNB，从而延长了人类祖细胞的增殖期。该成果揭示了共有基因的时空调节变化**如何驱动物种特异性的脑部特征，并为理解和干预神经发育疾病提供了分子模型。References:* Javed A, Gomez L, Pravata V, et al. Developmental gene expression patterns driv...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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