107. Nitric Oxide, LDL and the Missing Link in Heart Disease | Peter Anderson

Why can two people with similar LDL levels experience radically different cardiovascular outcomes?  In this episode, I speak with Peter Anderson about the possibility that endothelial nitric oxide may be one of the major variables separating these outcomes.We explore whether nitric oxide can be understood as a protective “bank” that is progressively depleted by ageing, hypertension, smoking, insulin resistance, obesity, sleep deprivation, psychological stress and circadian disruption.We also discuss dietary nitrate, rocket and beetroot, oral bacteria, sunlight, ultraviolet A, infrared light, movement, erectile function, flow-mediated dilation, ketosis, statins, calcium scores and the emerging controversy surrounding coronary CT analysis in lean-mass hyper-responders.CONSULT DR MAX🩺 Comprehensive Health Consulting & second opinion - www.drmaxgulhane.com/consultingSUPPORT MY WORK🎤 PRIVATE MEMBERS GROUP on Skool platform - weekly Q&A, my 52-page eBook, PDF resource downloads & more. USD20/month, cancel anytime.  https://www.skool.com/dr-maxs-circadian-reset🚨 DAYLIGHT COMPUTER. Blue-light free computer that doesn't wreck your circadian rhythm. Now shipping around the world. Code DRMAX for $25 off.   https://buy.daylightcomputer.com/DRMAX🚨 VIVA RAYS. Premium blue light blocking glasses with the most useful 3 in 1 clip on frame sets. Code DRMAX for 15% off. https://vivarays.com/dr-maxgulhane🚨 GEMBA RED. Highest quality photobiomodulation / redlight therapy devices, shipping within the USA. Code DRMAX for 10% off. https://gembared.comTIMESTAMPS04:38 Why similar cholesterol levels produce different outcomes06:16 Nitric oxide, eNOS and the endothelial “bank”09:00 How lipoproteins become retained in the arterial wall13:50 LDL as a midstream rather than sole upstream factor16:11 Lipid-lowering therapy and the “sledgehammer” problem19:17 Atherosclerosis as a redox and endothelial disease20:59 Flow-mediated dilation and real-time vascular assessment26:20 Erectile dysfunction as an early vascular warning sign28:19 Why standard lipid profiles can miss cardiovascular disease31:19 Dietary nitrate and the DASH diet33:36 Nitrate-rich food as vascular medicine37:00 Citrulline, ageing and reduced eNOS function40:25 Oral bacteria, mouthwash and blood pressure41:40 Sunlight, skin nitrate stores and nitric oxide43:48 Circadian regulation of eNOS46:26 Shift work, melatonin and endothelial repair50:22 Ketosis, beta-hydroxybutyrate and eNOS coupling52:36 Traditional populations, movement and vascular health57:53 Exercise, soft plaque and sudden cardiac events01:03:42 When might statin therapy be appropriate?01:11:27 The keto-CTA and lean-mass hyper-responder controversy01:17:34 Studying people who regress plaque despite high LDL01:21:37 Lipoprotein(a) and eNOS uncoupling01:27:14 Infrared light, fourth-phase water and blood flow01:33:52 Peter’s practical vascular-health frameworkFollow DR MAXWebsite: https://drmaxgulhane.com/Private Group: https://www.skool.com/dr-maxs-circadian-resetCourses: https://drmaxgulhane.com/collections/coursesX: https://twitter.com/MaxGulhaneMDInstagram: https://www.instagram.com/dr_max_gulhane/Apple Podcasts:  https://podcasts.apple.com/podcast/id1661751206Spotify:  https://open.spotify.com/show/6edRmG3IFafTYnwQiJjhwRLinktree: https://linktr.ee/maxgulhanemdDISCLAIMER: The content in this podcast is purely for informational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Do not disregard professional medical advice or delay in seeking it because of something you have heard on this podcast or YouTube channel. Do not make medication changes without first consulting your treating clinician.#NitricOxide #EndothelialHealth #Atherosclerosis #HeartDisease #CardiovascularHealth #LDLCholesterol #ApoB #EndothelialDysfunction #eNOS #Glycocalyx #LipoproteinRetention #CoronaryArteryDisease #VascularHealth #FlowMediatedDilation #DietaryNitrates #Beetroot #Rocket #Arugula #SunlightHealth #CircadianRhythm #ErectileDysfunction #BloodPressure #PlaqueStabilisation #CalciumScore #Statins #MetabolicHealth #InsulinResistance #OxidativeStress #KetoDiet #LeanMassHyperResponder #RegenerativeHealth #DrMaxGulhane #PeterAndersonSend us Fan Mail🧡 HARDBLOCK Australia's Longest Running Bitcoin-only (₿) ExchangeUse code REGENPOD for AUD 10 of bitcoin post account verification Support the show