EPISODE · Jun 2, 2026 · 21 MIN
1070-LinCx：利用工程化电突触进行脑回路长效编辑
from 聊聊Sci
这篇研究介绍了一种名为LinCx的新型神经环路编辑技术，旨在精确调节哺乳动物大脑中的电信号。由于天然连接蛋白在同种细胞间容易产生非特异性连接，研究人员利用白鲈鱼的蛋白开发出了具有排他性异源对接特征的工程化电突触。通过计算建模、蛋白质诱变以及一种名为FETCH的新型体外检测手段，团队成功设计出了仅能与彼此配对、而不会与哺乳动物自身蛋白结合的突触组件。该系统已在线虫和小鼠体内得到验证，能够通过增强特定神经元对之间的通信来有效改变生物行为。这项成果为治疗神经环路功能障碍提供了一种具备高空间精准度和长期稳定性的生物工程方案。References:Ransey E, Thomas G E, Wisdom E M, et al. Long-term editing of brain circuits using an engineered electrical synapse[J]. Nature, 2026: 1-13.前往小宇宙评论区与主播互动
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1070-LinCx：利用工程化电突触进行脑回路长效编辑
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