1072-泛癌侵袭性B细胞图谱

这项研究利用单细胞测序技术，对269名患者及20种不同癌症类型中的肿瘤浸润B细胞进行了系统性的全面分析。研究人员通过整合转录组、免疫组库和染色质可访问性数据，成功识别出15种B细胞亚群，并揭示了生发中心（GC）与滤泡外（EF）两条独立的细胞分化路径。研究重点指出，由非典型记忆B细胞（AtM）驱动的EF路径与癌症病情的恶化及免疫治疗耐药性密切相关。此外，研究阐明了代谢-表观遗传网络在调控B细胞分化中的关键作用，特别是谷氨酰胺代谢如何影响肿瘤环境。这些发现为理解癌症中的体液免疫提供了新蓝图，并为开发以B细胞为靶点的新型免疫疗法奠定了基础。References:* Ma J, Wu Y, Ma L, et al. A blueprint for tumor-infiltrating B cells across human cancers[J]. Science, 2024, 384(669...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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1072-泛癌侵袭性B细胞图谱

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