EPISODE · Jun 6, 2026 · 21 MIN
1088-炎症驱动的表观遗传衰老与多病性研究
from 聊聊Sci
这项研究深入探讨了慢性炎症（炎性衰老）与DNA甲基化改变这两大衰老标志之间的复杂联系。科研人员通过分析四个不同年龄和健康状况的独立队列，发现能够预测健康寿命的表观遗传时钟（如GrimAge和PhenoAge）比仅关联寿命的时钟更易受炎症蛋白影响。研究特别指出，干扰素相关炎性蛋白（如CXCL9、CXCL10等）不仅随年龄增长而增加，更是导致表观遗传年龄加速以及多种老年慢性病的因果驱动因素。此外，衰老还导致免疫细胞对微生物刺激的反应能力失调。这些发现表明，干扰素信号通路有望成为延缓衰老及治疗相关疾病的关键干预靶点。References:Liu Z, Ziogas A, Zhang Y, et al. Interferon-related inflammaging links epigenetic age acceleration to multimorbidity[J]. Cell Genomics, 2026.前往小宇宙评论区与主播互动
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1088-炎症驱动的表观遗传衰老与多病性研究
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