EPISODE · Jun 7, 2026 · 23 MIN
1091-人多能干细胞衍生窦房结与心丛类组装体模型
from 聊聊Sci
这篇研究介绍了一种由人类多能干细胞衍生的窦房结-心脏神经丛组装体，该模型成功模拟了心脏起搏系统的神经支配与发育成熟过程。研究人员通过整合窦房结类器官（SANOs）、心脏神经节类器官（CGPOs）及房性心脏类器官，构建了反映神经-起搏-心房传导轴的三联组装体。该平台不仅揭示了副交感神经如何调节心率自动性，还鉴定出PSAP-GPR37信号轴在促进起搏细胞成熟中的关键作用。此外，该模型能够有效模拟家族性缓慢性心律失常等遗传性疾病，并用于测试药物反应。这项工作为深入探索人类心脏起搏系统的发育机制、神经调控及传导疾病提供了高度仿生的体外研究工具。References:Zhang T, Fan L, Yao F, et al. Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems[J]. Cell Stem Cell, 2026.前往小宇宙评论区与主播互动
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1091-人多能干细胞衍生窦房结与心丛类组装体模型
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