EPISODE · Jun 7, 2026 · 18 MIN
1093-猪胆酸重塑新生儿免疫耐受与肠道菌群构建
from 聊聊Sci
这份研究通过多方面的实验揭示了猪胆酸（HCAs）在婴儿早期发育中扮演的关键角色。研究发现，这种由胎儿肝脏CYP3A7酶产生的独特胆汁酸在新生儿肠道中含量极高，但会随年龄增长而显著减少。HCAs能有效调节肠道免疫平衡，通过诱导调节性T细胞（Treg）的分化并抑制促炎的Th17细胞，为有益菌群的定植创造了免疫耐受环境。动物实验和人体队列数据共同证实，高水平的HCAs能显著降低新生儿患坏死性小肠结肠炎、感染及过敏性疾病的风险。该研究将HCAs定义为继胆酸和鹅去氧胆酸之后的“第三类初级胆汁酸”，为预防早期炎症性疾病提供了全新的生物标志物和代谢干预思路。References:Zheng X, Wang J, Sun Y, et al. Hyocholic acids shape neonatal immune tolerance and microbiota assembly[J]. Cell Metabolism, 2026.前往小宇宙评论区与主播互动
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1093-猪胆酸重塑新生儿免疫耐受与肠道菌群构建
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