EPISODE · Jun 7, 2026 · 20 MIN
1094-定制CAR单核细胞协同清除心肌纤维化与促进再生
from 聊聊Sci
这项研究介绍了一种名为pCAR-Mos的新型工程化单核细胞疗法，旨在治疗心肌梗死。该疗法通过基因工程使单核细胞表达能识别FAP蛋白的嵌合抗原受体，并分泌具有再生能力的Agrin蛋白。这种双效机制不仅能靶向清除导致病理性纤维化的成纤维细胞，还能同步促进心肌细胞再生与血管新生。实验证明，相较于传统的T细胞或巨噬细胞疗法，pCAR-Mos在心肌损伤区域表现出更强的定向迁移能力与组织渗透性。最终，该策略通过重塑心脏微环境，显著缩小了梗死面积并改善了心脏功能，为纤维化心脏疾病提供了安全且可逆的治疗前景。References:Wu Z, Zou X, Chen C, et al. Engineered CAR-monocytes coordinate fibrosis clearance and cardiac regeneration following myocardial infarction[J]. Cell Stem Cell, 2026.前往小宇宙评论区与主播互动
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1094-定制CAR单核细胞协同清除心肌纤维化与促进再生
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