EPISODE · Jun 7, 2026 · 23 MIN
1095-急性髓系白血病细胞亚型对维奈克拉耐药性的决定作用
from 聊聊Sci
这项研究揭示了急性髓系白血病（AML）中存在四种不同的白血病干细胞（LSC）亚型，这些亚型决定了患者对药物维奈克拉（venetoclax）的耐药性。研究人员通过对超过150名患者的分子谱分析发现，LAMP5+单核/树突状（MoDe）干细胞是导致耐药的关键因素之一。此外，白血病干细胞具有可塑性，能够向巨核/红系（MEP）状态转变，从而避开药物攻击。针对这些特定的脆弱点，研究建议使用MEK1/2抑制剂针对MoDe型细胞，或使用BCL-xL抑制剂针对MEP型细胞。这种基于生物标志物的分类方法为克服AML耐药性提供了精准的靶向治疗策略。References:Waclawiczek A, Leppä A M, Renders S, et al. Leukemic stem cell subtypes determine venetoclax resistance and therapeutic vulnerabilities in AML[J]. Cell stem cell, 2026.前往小宇宙评论区与主播互动
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1095-急性髓系白血病细胞亚型对维奈克拉耐药性的决定作用
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