11 20 2023

Hi, This Week in Medicine, we will be discussing recently published articles.New England Journal of MedicineFirst-Line Selpercatinib or Chemotherapy and Pembrolizumab in RET Fusion–Positive NSCLC  Phase 3 Trial of Selpercatinib in Advanced RET-Mutant Medullary Thyroid Cancer  Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease  Arginine or Hypertonic Saline–Stimulated Copeptin to Diagnose AVP Deficiency  Journal of  American Medical AssociationEffect of Dietary Sodium on Blood PressureA Crossover Trial  Intravenous Vitamin C for Patients Hospitalized With COVID-19 Two Harmonized Randomized Clinical Trials  Multitarget Stool RNA Test for Colorectal Cancer Screening  Hypertension journalDifferent Home Blood Pressure Thresholds to Predict Perfect 24-Hour Ambulatory Blood Pressure Control in Treated Hypertension Based on an “All-in-One” Device Annals of Internal MedicineAtezolizumab With or Without Radiotherapy for Advanced Squamous Cell Carcinoma of the Penis (The PERICLES Study): A Phase II Trial Journal of Clinical OncologyZanubrutinib Versus Ibrutinib in Symptomatic Waldenström Macroglobulinemia: Final Analysis From the Randomized Phase III ASPEN Study HepatologyMicroscopic colitis and risk of incident rheumatoid arthritis  Clinical GastroenterologyThe Impact of Intermittent Fasting on Patients With Suspected Gastroesophageal Reflux Disease  Clinical Infectious DiseasesPleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum  Journal of infectious DiseasesHepatitis B e Antigen-Negative Single Hepatocyte Analysis Shows Transcriptional Silencing and Slow Decay of Infected Cells With Treatment Journal of Clinical Rheumatology Barriers and Enablers in the Use of Parenteral Methotrexate in Rheumatoid Arthritis Patients: A Scoping Review  Arthritis and RheumatologyAssociation of Interosseous Tendon Inflammation in the Hand With Different Early Arthritides in a 10-Year Magnetic Resonance Imaging Study Association Between Plasma Rituximab Concentration and the Risk of Major Relapse in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides During Rituximab Maintenance Therapy  Circulation October 24, 2023 Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery American College of Cardiology SGLT2 Inhibitors for Cancer Therapy–Related Cardiac Dysfunction   Journal of Clinical Endocrinology & MetabolismEffects of Aerobic Training and Semaglutide Treatment on Pancreatic β-Cell Secretory Function in Patients With Type 2 Diabetes Neurology:Eligibility for Anti-Amyloid Treatment in a Population-Based Study of Cognitive Aging   Chest Preserved Ratio Impaired Spirometry and Risks of Macrovascular, Microvascular Complications and Mortality Among Individuals With Type 2 Diabetes  The American Journal of Respiratory and Critical Care MedicineAugmentation Therapy for Severe Alpha-1 Antitrypsin Deficiency Improves Survival and Is Decoupled from Spirometric Decline—A Multinational Registry Analysis Clinical Gastroenterology AND HepatologyRisk of Postcolonoscopy Thromboembolic Events: A Real-World Cohort Study The Role of Carbamoyl Phosphate Synthetase 1 as a Prognostic Biomarker in Patients With Acetaminophen-induced Acute Liver Failure  Clinical Journal of American Society of NephrologyDifferences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait Prostaglandin E2, Osmoregulation, and Disease Progression in Autosomal Dominant Polycystic Kidney Disease  Kidney International reportsRandomized Study of Tenapanor Added to Phosphate Binders for Patients With Refractory Hyperphosphatemia