11 20 2023

Hi, This Week in Medicine, we will be discussing recently published articles.

New England Journal of Medicine

First-Line Selpercatinib or Chemotherapy and Pembrolizumab in RET Fusion–Positive NSCLC 

 Phase 3 Trial of Selpercatinib in Advanced RET-Mutant Medullary Thyroid Cancer 

 Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease 

 Arginine or Hypertonic Saline–Stimulated Copeptin to Diagnose AVP Deficiency 

 Journal of  American Medical Association

Effect of Dietary Sodium on Blood PressureA Crossover Trial 

 Intravenous Vitamin C for Patients Hospitalized With COVID-19 

Two Harmonized Randomized Clinical Trials 

 Multitarget Stool RNA Test for Colorectal Cancer Screening 

 Hypertension journal

Different Home Blood Pressure Thresholds to Predict Perfect 24-Hour Ambulatory Blood Pressure Control in Treated Hypertension Based on an “All-in-One” Device

 Annals of Internal Medicine

Atezolizumab With or Without Radiotherapy for Advanced Squamous Cell Carcinoma of the Penis (The PERICLES Study): A Phase II Trial

Journal of Clinical Oncology

Zanubrutinib Versus Ibrutinib in Symptomatic Waldenström Macroglobulinemia: Final Analysis From the Randomized Phase III ASPEN Study

 Hepatology

Microscopic colitis and risk of incident rheumatoid arthritis

  Clinical Gastroenterology

The Impact of Intermittent Fasting on Patients With Suspected Gastroesophageal Reflux Disease

  Clinical Infectious Diseases

Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum

  Journal of infectious Diseases

Hepatitis B e Antigen-Negative Single Hepatocyte Analysis Shows Transcriptional Silencing and Slow Decay of Infected Cells With Treatment

 Journal of Clinical Rheumatology 

Barriers and Enablers in the Use of Parenteral Methotrexate in Rheumatoid Arthritis Patients: A Scoping Review

  Arthritis and Rheumatology

Association of Interosseous Tendon Inflammation in the Hand With Different Early Arthritides in a 10-Year Magnetic Resonance Imaging Study

Association Between Plasma Rituximab Concentration and the Risk of Major Relapse in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides During Rituximab Maintenance Therapy

  Circulation October 24, 2023 

Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery

American College of Cardiology

SGLT2 Inhibitors for Cancer Therapy–Related Cardiac Dysfunction 

  Journal of Clinical Endocrinology & Metabolism

Effects of Aerobic Training and Semaglutide Treatment on Pancreatic β-Cell Secretory Function in Patients With Type 2 Diabetes

 Neurology:

Eligibility for Anti-Amyloid Treatment in a Population-Based Study of Cognitive Aging

  Chest

 Preserved Ratio Impaired Spirometry and Risks of Macrovascular, Microvascular Complications and Mortality Among Individuals With Type 2 Diabetes

 The American Journal of Respiratory and Critical Care Medicine

Augmentation Therapy for Severe Alpha-1 Antitrypsin Deficiency Improves Survival and Is Decoupled from Spirometric Decline—A Multinational Registry Analysis

 Clinical Gastroenterology AND Hepatology

Risk of Postcolonoscopy Thromboembolic Events: A Real-World Cohort Study

The Role of Carbamoyl Phosphate Synthetase 1 as a Prognostic Biomarker in Patients With Acetaminophen-induced Acute Liver Failure

  Clinical Journal of American Society of Nephrology

Differences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait

Prostaglandin E2, Osmoregulation, and Disease Progression in Autosomal Dominant Polycystic Kidney Disease

  Kidney International reports

Randomized Study of Tenapanor Added to Phosphate Binders for Patients With Refractory Hyperphosphatemia