11 25 2024

Hi, This Week in Medicine, we will be discussing

 in New England Journal of Medicine

Nationwide, Couple-Based Genetic Carrier Screening

Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma

Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite

  Journal of  American Medical Association

Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores

Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a): A Phase 2 Randomized Clinical Trial

 Annals of Internal Medicine

The Effect of Denosumab on Risk for Emergently Treated Hypocalcemia by Stage of Chronic Kidney Disease

  British Medical Journal

Nurse and doctor turnover and patient outcomes in NHS acute trusts in England

 Lancet

Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan

  Cancer Journal for Clinicians

Efficacy and safety of nivolumab monotherapy in patients with unresectable clear cell sarcoma and alveolar soft part sarcoma 

 Journal of Clinical Oncology

Trastuzumab Deruxtecan in Advanced Solid Tumors With Human Epidermal Growth Factor Receptor 2 Amplification Identified by Plasma Cell-Free DNA Testing: A Multicenter, Single-Arm, Phase II Basket Trial

  Hepatology

Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide

Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD

 Gastroenterology

 Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome

 Clinical Gastroenterology

 Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD

  Clinical Infectious Diseases

Prevalence, Clinical Severity, and Serotype Distribution of Pneumococcal Pneumonia Among Adults Hospitalized With Community-Acquired Pneumonia in Tennessee and Georgia, 2018–2022

 Rheumatology 

Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis

  Journal of Clinical Rheumatology 

Prevalence and Clinical Implications of Autoantibodies in Juvenile Dermatomyositis: A Single-Center Experience From India

   Circulation

Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction

 Journals of the American College of Cardiology

Complete vs Culprit-Only Revascularization in Older Patients With Myocardial Infarction With or Without ST-Segment Elevation

  JAMA Cardiology

Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection FractionThe AMETHYST Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Hemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes

 Diabetes care

Trends in Racial and Ethnic Disparities in Early Glycemic Control Among Veterans Receiving Care in the Veterans Health Administration, 2008–2019 

  Neurology

Quantitative MRI Measures and Cognitive Function in People With Drug-Resistant Juvenile Myoclonic Epilepsy

 Chest

Air Pollution Metabolomic Signatures and Chronic Respiratory Diseases Risk

A Longitudinal Study

  The American Journal of Respiratory and Critical Care Medicine

Lung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI)

  Clinical Journal of American Society of Nephrology

Physical Function and Mortality in Older Adults with Chronic Kidney Disease

 Kidney International reports

Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT