11 25 2024

Hi, This Week in Medicine, we will be discussing  in New England Journal of MedicineNationwide, Couple-Based Genetic Carrier Screening Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite  Journal of  American Medical AssociationEvaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a): A Phase 2 Randomized Clinical Trial Annals of Internal MedicineThe Effect of Denosumab on Risk for Emergently Treated Hypocalcemia by Stage of Chronic Kidney Disease  British Medical JournalNurse and doctor turnover and patient outcomes in NHS acute trusts in England LancetInduced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan  Cancer Journal for CliniciansEfficacy and safety of nivolumab monotherapy in patients with unresectable clear cell sarcoma and alveolar soft part sarcoma  Journal of Clinical OncologyTrastuzumab Deruxtecan in Advanced Solid Tumors With Human Epidermal Growth Factor Receptor 2 Amplification Identified by Plasma Cell-Free DNA Testing: A Multicenter, Single-Arm, Phase II Basket Trial  HepatologySodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD Gastroenterology Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome Clinical Gastroenterology  Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD  Clinical Infectious DiseasesPrevalence, Clinical Severity, and Serotype Distribution of Pneumococcal Pneumonia Among Adults Hospitalized With Community-Acquired Pneumonia in Tennessee and Georgia, 2018–2022 Rheumatology Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis  Journal of Clinical Rheumatology Prevalence and Clinical Implications of Autoantibodies in Juvenile Dermatomyositis: A Single-Center Experience From India   CirculationSingle-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction Journals of the American College of CardiologyComplete vs Culprit-Only Revascularization in Older Patients With Myocardial Infarction With or Without ST-Segment Elevation  JAMA CardiologyVerinurad Plus Allopurinol for Heart Failure With Preserved Ejection FractionThe AMETHYST Randomized Clinical Trial Journal of Clinical Endocrinology & MetabolismHemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes Diabetes careTrends in Racial and Ethnic Disparities in Early Glycemic Control Among Veterans Receiving Care in the Veterans Health Administration, 2008–2019   NeurologyQuantitative MRI Measures and Cognitive Function in People With Drug-Resistant Juvenile Myoclonic Epilepsy  ChestAir Pollution Metabolomic Signatures and Chronic Respiratory Diseases RiskA Longitudinal Study  The American Journal of Respiratory and Critical Care MedicineLung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI)   Clinical Journal of American Society of NephrologyPhysical Function and Mortality in Older Adults with Chronic Kidney Disease Kidney International reportsAssociations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT