11 4 2024

Hi, This Week in Medicine, we will be discussing  New England Journal of MedicineOnce-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis  Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis  from Journal of  American Medical Association Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial FibrosisThe EVOLVED Randomized Clinical Trial Annals of Internal MedicineProjected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer Comparative Effectiveness and Safety of Atorvastatin Versus Rosuvastatin: A Multi-database Cohort Study  British Medical JournalComparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies LancetThe effect of tranexamic acid on postpartum bleeding in women with moderate and severe anaemia (WOMAN-2): an international, randomised, double-blind, placebo-controlled trial Journal of Clinical OncologyRandomized Phase II Trial of Immunotherapy-Based Total Neoadjuvant Therapy for Proficient Mismatch Repair or Microsatellite Stable Locally Advanced Rectal Cancer (TORCH) journal of HepatologyHistological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH GastroenterologyA Single-Cell Atlas of the Murine Pancreatic Ductal Tree Identifies Novel Cell Populations With Potential Implications in Pancreas Regeneration and Exocrine Pathogenesis Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA)  Clinical Infectious DiseasesEvidence-Informed Provision of Doxycycline Post-Exposure Prophylaxis for Prevention of Bacterial Sexually Transmitted InfectionsAbstract  Rheumatology Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic: Insights From a Quality Improvement Project at a Tertiary Rheumatology Center  CirculationRNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative Splicing Journals of the American College of CardiologyUrinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis JAMA CardiologyLeadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure Journal of Clinical Endocrinology & MetabolismIncreased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas  Diabetes careSitting Time and Its Interaction With Physical Activity in Relation to All-Cause and Heart Disease Mortality in U.S. Adults With Diabetes  The American Journal of Respiratory and Critical Care MedicineThe Effect of Positive End-Expiratory Pressure on Pulmonary Vascular Resistance Depends on Lung Recruitability in Patients with Acute Respiratory Distress SyndromeRationale: A U-shaped relationship should exist between lung volume and  Kidney International reportsProspective Trial on the Pharmacokinetics of Clopidogrel in Hemodialysis Patients A Survey on End-of-Life Contemplation Among Patients on Dialysis