1101-计算设计工程化聚酯水解酶PHL7高效降解PET

这篇文章详细阐述了通过计算工程学改造聚酯水解酶PHL7的过程，旨在提升其在生物催化循环中的稳定性和降解效率。研究团队结合了Rosetta PROSS算法与理性设计，成功开发出具备极高热稳定性（熔点可达88-95 °C）且对盐浓度依赖性较低的多突变变体。在模拟工业生产的高底物浓度条件下，优化后的变体如R4M10-H185Y表现卓越，在24小时内对PET的降解率最高可达84%。通过X射线晶体结构分析和分子动力学模拟，研究揭示了突变如何通过重塑活性位点和增强结构刚性来提升性能。这些高性能的PHL7变体为实现大规模、可持续的塑料回收提供了强有力的生物催化工具。References:Blázquez-Sánchez P, Gunkel J, Useini A, et al. Computational engineering of the polyester hydrolase PHL7 for efficient poly (ethylene terephthalate) degradation in biocatalytic recycling processes[J]. Nature Communications, 2026, 17(1): 4370.前往小宇宙评论区与主播互动

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1101-计算设计工程化聚酯水解酶PHL7高效降解PET

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