EPISODE · Jun 9, 2026 · 17 MIN
1103-合成重写人类免疫球蛋白重链基因座
from 聊聊Sci
这项研究展示了人工合成人类免疫球蛋白重链（SynIgh）基因座的从头设计与全合成，并成功将其应用于小鼠模型。研究人员开发了一种名为“稳定剂”的融合蛋白，克服了合成超长重复DNA序列的稳定性难题，构建出包含174kb序列的人造基因库。该合成基因座集成了来自全球人群的V、D、J基因片段，通过引入mSCRaMbLE可编程重排系统，能够在活体细胞内诱导基因组洗牌。实验证实，SynIgh小鼠不仅能进行正常的V(D)J重组，还能通过人工诱导的重排进一步提升抗体重组的多样性。这一成果打破了天然基因座在空间结构上的束缚，为哺乳动物基因组重写和抗体多样性研究提供了高度灵活的通用框架。References:Fu Z H, Ma Y, Cheng S, et al. Synthetic rewriting of the IGH locus[J]. Cell Genomics, 2026.前往小宇宙评论区与主播互动
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