1105-人蝠冠状病毒蛋白相互作用图谱与跨物种传播机制研究

这项研究通过蛋白质相互作用图谱，对比了新冠病毒 (SARS-CoV-2) 及其蝙蝠起源近亲 RaTG13 在人类与大马蹄蝠细胞中的行为差异。研究人员发现，病毒仅需极小的基因变异即可重塑其与宿主的互动网络，其中Orf9b蛋白的第72位残基发挥了关键的“分子开关”作用。在人类细胞中，该位点增强了与 Tom70 的结合以逃避先天免疫，而在蝙蝠细胞中，它则倾向于结合限制因子 MTARC2 从而抑制病毒复制。此外，研究还确定了核壳蛋白 (N) 的单点突变是病毒跨物种适应蝙蝠细胞的关键。这些发现揭示了冠状病毒如何通过微小的序列演化突破物种屏障，为预测和应对未来人畜共患病的爆发提供了重要线索。References:Batra J, Rutkowska M, Zhou Y, et al. Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential[J]. Cell Host & Microbe, 2026.前往小宇宙评论区与主播互动

Episode metadata supplied by the publisher feed · Published Jun 9, 2026

Embed this episode

Attribution link and audio player

Ready to play

1105-人蝠冠状病毒蛋白相互作用图谱与跨物种传播机制研究

0:00 28:29

1×

No transcript for this episode yet

We transcribe on demand. Request one and we'll notify you when it's ready — usually under 10 minutes.

Share this episode

Similar Episodes

No similar episodes found.

Similar Podcasts

Forfeiture Book Review: Ecocide and Sci-Fi JP et al. A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra Deep Dream State Neural Nets And Pretty Patterns Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.

Frequently Asked Questions

How long is this episode of 聊聊Sci?

This episode is 28 minutes long.

When was this 聊聊Sci episode published?

This episode was published on June 9, 2026.

Can I download this 聊聊Sci episode?

Yes. Use the download control on the episode player to save the publisher-provided media file.

URL copied to clipboard!