111. 6 Peptides to Support The Gut & Aid in Digestion (Peptides Episode) - AT-1001, KPV, BPC-157, and More (+ a Deep Dive into What Each One Specifically Targets)

In this episode, we set the stage by going through the intricate anatomy of the gut lining, providing a comprehensive understanding of its layers and cellular components. We, then, explore how six gut-supporting peptides and compounds offer promising therapeutic avenues. From larazotide acetate's tight-junction regulation to KPV's anti-inflammatory properties and BPC-157's reparative effects, we dive into the diverse mechanisms by which these peptides contribute to gut health. Topics: 1. Anatomy of the Gut Lining - Layers of Mucus - Varying thickness in different parts of the intestine - Composition: water, mucins, glycoproteins - Intestinal Epithelium - Tight junctions - Renewal every 3 to 5 days - Villi and Crypts - Increase in surface area - Stem cells in crypts for cellular renewal - Microvilli - Amplification of absorptive surface area 2. Lamina Propria - Contains blood vessels and lymphatic vessels - Rich in immune cells: - Lymphocytes (T cells, B cells) - Macrophages - Dendritic cells - Mast cells - Eosinophils 3. Types of Epithelial Cells - Enterocytes - Goblet cells - Paneth cells - M cells - Enteroendocrine cells - Stem cells 4. Tight Junctions - Composition: claudins, occludin, junctional adhesion molecules - Interaction with cytoskeleton (ZO proteins) - Dynamic regulation - Role in permeability 5. Disruption of Tight Junctions - Zonulin release - Mechanism of increased permeability 6. Gut-Supporting Peptides and Compounds - Larazotide acetate (AT-1001) - Tight-junction regulator (think "leaky gut") - Zonulin receptor antagonist - KPV - Sequence of amino acids from alpha-MSH - Anti-inflammatory - BPC-157 (Body Protection Compound) - Derived from human gastric juice - Protective and reparative effects 7. Additional Gut-Supporting Peptides - Suprefort Pancreas peptides - Svetinorm Liver peptides - Stamakort Stomach peptides Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!