EPISODE · Jun 11, 2026 · 23 MIN
1111-含硫氨基酸饮食通过NKT-XCL1-cDC1轴增强结肠癌免疫治疗
from 聊聊Sci
此研究揭示了膳食硫氨基酸（Saa）通过重塑肠道生态来增强结肠癌抗肿瘤免疫的机制。高 Saa 饮食能增加肠道粘液厚度并促进鼠粘螺菌（M. schaedleri）的繁衍，这种细菌会诱导自然杀伤 T（NKT）细胞分泌趋化因子 XCL1。该信号分子随后募集并激活1型常规树突状细胞（cDC1），进而增强CD8+ T 细胞的抗肿瘤效能。通过整合人类宏基因组分析与小鼠模型实验，研究证明了这种“饮食-微生物-免疫”轴能有效遏制肿瘤生长。这些发现为利用营养干预辅助癌症免疫治疗提供了重要的新方向。References:Lobel L, Fonseca-Pereira D, Nakatsu G, et al. Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit[J]. Immunity, 2026.前往小宇宙评论区与主播互动
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1111-含硫氨基酸饮食通过NKT-XCL1-cDC1轴增强结肠癌免疫治疗
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