EPISODE · Jun 11, 2026 · 20 MIN
1113-人源麻疹病毒中和抗体及其结构机制研究
from 聊聊Sci
这份研究详述了从麻疹疫苗接种者体内分离出的一系列人源单克隆抗体，这些抗体能有效针对病毒表面的血凝素 (H) 和融合蛋白 (F)。通过高分辨率冷冻电子显微镜，科学家精确绘制了抗体与病毒蛋白结合的表位图谱，揭示了多个高度保守的攻击位点。实验证明，其中一些抗体表现出皮摩尔级的极高综合中和效力，能够跨菌株阻断病毒感染。在动物实验中，这些抗体无论是在感染前作为预防还是感染后作为治疗，都能显著降低病毒载量。该发现为开发应对全球麻疹疫情反弹的新型预防和治疗药物提供了关键的分子基础与临床路径。References:Acciani M, Zyla D, Niemeyer G, et al. Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins[J]. Cell Host & Microbe, 2026.前往小宇宙评论区与主播互动
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1113-人源麻疹病毒中和抗体及其结构机制研究
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