EPISODE · Jun 12, 2026 · 18 MIN
1119-CD19-CAR T 细胞治疗系统性硬化症引发的皮肤组织再生
from 聊聊Sci
这篇文章探讨了CD19-CAR T细胞疗法在治疗系统性硬化症（SSc）这种自身免疫性疾病中的潜力。通过对患者皮肤活检样本进行空间转录组学和成像质谱流式技术分析，研究人员发现该疗法不仅能深度清除B细胞，还能显著诱导皮肤组织的结构再生。结果显示，患者受损的真皮乳头得到了恢复，成纤维细胞从致病状态转向了健康的生理状态，同时伴有血管修复和表皮功能的改善。这项研究为逆转以往被认为不可逆的组织纤维化提供了关键的分子和细胞水平证据。总体而言，文章揭示了免疫细胞疗法在推动器官再生和治疗硬化性疾病方面的广阔前景。References:Rius Rigau A, Xu M, Liu Z, et al. Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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1119-CD19-CAR T 细胞治疗系统性硬化症引发的皮肤组织再生
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