112:: Ovarian aging 101: the longevity metric for women in their 20s and 30s

The entire longevity conversation forgot about female bodies, so we are fixing that today. It turns out your ovaries are the fastest aging organ you have, declining measurably in your mid 30s, and researchers now consider ovarian aging one of the most important longevity markers we have for women. In this episode we break down why your ovaries age more than twice as fast as the rest of you, how ovarian aging connects to your heart, bones, and brain, what AMH and your family menopause timeline can tell you, and the everyday habits that actually protect your ovarian longevity. Smart, fun, and something you can actually act on this week.I'm Dr. Kelsy Vick, a board certified orthopedic Doctor of Physical Therapy and women's health PT, and this is Wellness Big Sis: The Pod, expert led, science backed wellness girl chats for women in their 20s and 30s.Want the deeper cuts and the studies? Subscribe to Smart Girl Newspaper, linked below.loving the pod? click the follow button, & we'd love if you could leave a review! thank you x 1000 :)sign up for the free Smart Girl Newspaper!insta:: @dr.kelsyvickdpt & @wellnessbigsispodyoutube:: @dr.kelsyvickdpttiktok:: @dr.kelsyvickdpt & @wellnessbigsispodLinks/Resources:RESOURCES: Ovaries age more than twice as fast as the rest of the body and are the fastest aging organ. This is the Columbia work led by Yousin Suh. Columbia University Irving Medical Center: Studying Ovaries to Understand How We All Age. https://www.cuimc.columbia.edu/news/studying-ovaries-understand-how-we-all-age Underlying research: Molecular and genetic insights into human ovarian aging from single nuclei multi omics analyses (2024). https://pubmed.ncbi.nlm.nih.gov/39578560/ Accessible longevity framing: https://time.com/collections/the-age-of-longevity/7338546/ovaries-unlock-secrets-longevity/Low AMH is linked to cardiovascular and metabolic risk markers. de Kat, A. C., et al. and related work: Low antimullerian hormone levels may be associated with cardiovascular risk markers in women with diminished ovarian reserve. https://pubmed.ncbi.nlm.nih.gov/26613901/ BMI nuance: https://academic.oup.com/jcem/article/105/3/e555/5581647Later menopause and a longer reproductive lifespan are associated with greater longevity. Shadyab, A. H., et al. (2017). Ages at menarche and menopause and reproductive lifespan as predictors of exceptional longevity in women: the Women's Health Initiative. Menopause. https://pmc.ncbi.nlm.nih.gov/articles/PMC5177476/Accelerated ovarian aging is driven by oxidative stress, mitochondrial dysfunction, and inflammation, and smoking is directly toxic to ovarian reserve.. Ovarian aging review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332606/