EPISODE · Jun 14, 2026 · 20 MIN
1130-SNHG9与肠道菌群调节药物性肝损伤的机制研究
from 聊聊Sci
这项研究揭示了肠道微生物群通过肝脏长链非编码RNA SNHG9保护肝脏免受药物损伤的新机制。研究发现，由乳酸杆菌产生的代谢产物2-羟基-2-甲基丁酸 (HMB) 能显著诱导肝脏中 SNHG9 的表达。该RNA通过与蛋白 IMP2 结合，抑制促炎因子 MYC 的翻译，从而上调受体 MAS 的水平并增强细胞自噬，有效缓解对乙酰氨基酚引起的肝损伤。临床数据进一步证实，肝损伤患者体内 SNHG9 和 HMB 的水平与疾病严重程度呈负相关。这一发现不仅确定了肠-肝轴中的关键分子通路，还为预防和治疗药物性肝损伤提供了潜在的益生菌或代谢干预方案。References:Bao W, Hang B, Zeng D, et al. Hepatic SNHG9 links gut microbiota to liver protection in drug-induced liver injury[J]. Nature Communications, 2026, 17(1): 4415.前往小宇宙评论区与主播互动
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1130-SNHG9与肠道菌群调节药物性肝损伤的机制研究
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