1157-ISG Atlas: Functional Map of Antiviral Innate Immunity

This research introduces The ISG Atlas, a comprehensive resource detailing how hundreds of interferon-stimulated genes (ISGs) modulate viral infections. By utilizing a time-resolved loss-of-function screen, the authors systematically analyzed the effects of 285 ISGs against a diverse panel of eight different viruses. The study identifies both pan-antiviral factors that work against many pathogens and virus-specific genes with more narrow targets. A key discovery highlights the protein BORCS8, which restricts SARS-CoV-2 by promoting the acidification of endosomes to degrade viral particles. Additionally, the researchers utilized machine learning and proteomic profiling to uncover functional synergies and novel proviral roles for certain genes. Collectively, this work provides a valuable framework for understanding innate immunity and identifying potential targets for future antiviral therapies.References:Krey K, Risso-Ballester J, Hamad S, et al. The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes[J]. Nature Communications, 2026, 17(1): 4206.前往小宇宙评论区与主播互动