EPISODE · Jun 21, 2026 · 19 MIN
1163-三阴性乳腺癌化疗响应的单细胞与空间转录组图谱
from 聊聊Sci
这项研究通过单细胞转录组和空间转录组技术，深入分析了101名三阴性乳腺癌患者在接受新辅助化疗前的肿瘤样本。研究人员将癌细胞划分为四种不同的患者水平亚型（原型），并识别出反映肿瘤内部差异的13种元程序。通过对近43万个细胞的观察，科学家们发现了八种由癌细胞、免疫细胞和间质细胞构成的生态型空间结构。研究强调，特定的巨噬细胞亚型及癌细胞的干扰素信号等特征与化疗的良好临床反应密切相关。该成果构建了未经治疗的三阴性乳腺癌精细图谱，为预测化疗疗效和开发个体化治疗方案提供了重要的生物学依据。References:Yan Y, Lin Y, Kumar T, et al. Ecotypes of triple-negative breast cancer in response to chemotherapy[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动
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1163-三阴性乳腺癌化疗响应的单细胞与空间转录组图谱
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