1164-精胺：抑制铁死亡的内源性铁螯合剂

这项研究揭示了精胺（Spermine）作为一种内源性铁螯合剂，通过限制细胞内游离铁的可用性来显著抑制铁死亡。研究发现，在肝细胞癌（HCC）的发生过程中，癌细胞通过激活ALDH18A1介导的代谢途径上调精胺合成，从而逃避铁死亡并促进肿瘤生长。相反，通过基因敲除或药物抑制该代谢轴，可以诱导肿瘤细胞发生铁死亡并削弱成瘤能力。此外，外源性补充精胺展现了显著的临床潜力，能够有效减轻肝脏、肠道和肾脏等多种器官的缺血再灌注损伤。总之，该研究不仅阐明了精胺在金属离子平衡和细胞保护中的新机制，还为癌症治疗和组织损伤预防提供了潜在的代谢干预策略。References:Li M, Yu X, Ouyang S, et al. Spermine is an endogenous iron chelator that inhibits ferroptosis[J]. Nature, 2026: 1-11.前往小宇宙评论区与主播互动

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