EPISODE · Jun 21, 2026 · 17 MIN
1165-ALT癌症中的着丝粒特征与端粒完整性维持
from 聊聊Sci
这项研究揭示了在采用替代端粒延长（ALT）机制的癌细胞中，原本界限分明的端粒与着丝粒之间存在异常的结构融合。研究人员发现，着丝粒α-卫星序列会由于非正常的基因重组而插入到端粒区域，并在该位置诱导形成特异性的CENP-A染色质足迹。这种现象在ALT阳性的儿童神经母细胞瘤及相关细胞系中表现尤为显著，且与ATRX蛋白缺失及DNA低甲基化导致的表观遗传失调密切相关。实验证明，这些异位嵌入的着丝粒成分并非单纯的基因组垃圾，而是对维持ALT癌症细胞端粒的染色质完整性起到了关键支撑作用。如果干预这一组装过程，会导致端粒受损并抑制癌细胞的生长，从而为针对ALT癌症的精准治疗提供了潜在的新靶点。References:Bhargava R, Mahlke M A, Schmidt T T, et al. Centromeric footprints preserve telomere integrity in ALT cancers[J]. Nature, 2026: 1-9.前往小宇宙评论区与主播互动
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1165-ALT癌症中的着丝粒特征与端粒完整性维持
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