EPISODE · Jun 22, 2026 · 22 MIN
1168-用于肺癌早期预防及风险预测的血浆蛋白标志物
from 聊聊Sci
这篇研究论文揭示了一种由 14种蛋白质组成的血浆特征指标，能够提前五年以上预测肺癌的发病风险。研究人员通过机器学习分析了英国生物样本库等大规模数据，发现该蛋白质信号在吸烟者和长期暴露于空气污染（细烟雾颗粒物）的人群中显著升高。实验表明，环境中的有害颗粒物会通过IL-1β炎症信号触发肺部细胞进入一种名为 KAC 的促癌过渡状态。重要的是，该蛋白质指标能有效筛选出那些可以通过抗炎症药物（IL-1β抑制剂）预防肺癌的高危个体，从而实现精准化预防。这项成果为在癌症形成前进行分子层面的早期干预提供了关键的生物标志物。References:Pandya T, Swanton C. Plasma signals of lung tumor promotion for molecular cancer prevention. Cell. 2026 Jun 4:S0092-8674(26)00522-2. doi: 10.1016/j.cell.2026.05.005. Epub ahead of print. PMID: 42242224.前往小宇宙评论区与主播互动
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1168-用于肺癌早期预防及风险预测的血浆蛋白标志物
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