EPISODE · Jun 23, 2026 · 14 MIN
1171-先天免疫细胞在肿瘤中的克隆谱系追踪
from 聊聊Sci
这项研究介绍了一种名为 Mitotrek 的新方法，利用单细胞多组学技术和线粒体 DNA（mtDNA）变异作为天然谱系标签，追踪人体癌症中先天免疫细胞的克隆起源。通过对肺癌和卵巢癌患者的肿瘤、健康组织及血液样本进行系统分析，研究人员证实了肿瘤内的骨髓细胞主要来源于循环系统中的单核细胞，而非局部扩增。研究特别发现，DC3s（三型树突状细胞）在克隆和表观遗传层面均与单核细胞紧密相关，揭示了其独特的发育路径。最关键的发现是，单核细胞的分化命运 bias（向巨噬细胞或树突状细胞分化）在进入肿瘤环境之前，就已经在外周血液中通过表观遗传程序被预先设定。这一发现挑战了肿瘤局部环境决定免疫细胞功能的传统观点，暗示肿瘤免疫反应在细胞浸润前就已受到系统性的影响。References:Liu V, Sandor K, Yan P .Clonal lineage tracing of innate immune cells in human cancer. Cancer Cell, 2026; 0前往小宇宙评论区与主播互动
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1171-先天免疫细胞在肿瘤中的克隆谱系追踪
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