EPISODE · Jun 24, 2026 · 22 MIN
1179-法尼基化驱动的KRAS相分离促进结肠肿瘤生长
from 聊聊Sci
这项研究揭示了KRAS蛋白通过液-液相分离（LLPS）形成细胞质凝聚体的新机制，该机制显著促进了结肠癌的生长。研究发现，KRAS在C185位点的法尼酰化修饰是驱动这种相分离的关键因素，且凝聚体水平与癌症的分期和不良预后呈正相关。在功能上，这些凝聚体通过招募RCE1酶来加速KRAS的后续加工与胞膜转运，从而放大致癌信号通路。通过对FDA批准药物的筛选，研究确认他汀类药物（如匹伐他汀）能有效抑制法尼酰化并破坏KRAS凝聚体，进而抑制肿瘤生长。此外，阻断KRAS相分离不仅能产生抗癌效果，还能显著增强肿瘤对G12C抑制剂（如AMG 510）的治疗敏感性，为克服耐药性提供了潜在方案。References:Wang X, Zhang Y, Lu M, et al. Farnesylation-driven KRAS phase separation promotes colon tumor growth[J]. Cell, 2026.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
1179-法尼基化驱动的KRAS相分离促进结肠肿瘤生长
0:00
22:43
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 22 minutes long.
When was this 聊聊Sci episode published?
This episode was published on June 24, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!