118: When Should You Consider an Antidepressant? episode artwork

EPISODE · Jun 22, 2026 · 28 MIN

118: When Should You Consider an Antidepressant?

from Your Checkup: Patient Education Health Podcast · host Ed Delesky, MD and Nicole Aruffo, RN

The hardest part about antidepressants is often not the pill, it is the question you ask yourself before you ever bring it up: “Is this serious enough?” We think that question keeps too many people stuck. We are Ed Delesky (family medicine doctor) and Nicole Aruffo (nurse), and we walk through a clearer test: is depression or anxiety affecting your ability to live your life the way you want to live it?We unpack the stigma that makes mental health feel different from every other medical problem, even though it lives in the brain like anything else. We use simple, patient-friendly analogies to explain how antidepressants work: a dimmer switch turned back up, or glasses that help you see more clearly. We also cover the practical signals we look for in primary care when deciding whether it is time to consider medication for depression or anxiety: symptoms lasting weeks to months, daily function taking a hit, sleep and motivation sliding, and foundational steps like therapy, movement, and sleep support not being enough on their own.We also demystify what starting an SSRI or SNRI can feel like, including why these medications usually take six to eight weeks to show real benefits and why a subtle improvement can still be life-changing. If you worry about dependence, personality changes, or taking something forever, we address those fears directly and talk about how many people use antidepressants for a season, not a lifetime. If this conversation helps, subscribe, share it with a friend, and leave a review so more people can find care that actually works.Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.Support the showProduction and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RNArtwork Rebrand and Avatars:Vantage Design Works (Vanessa Jones) Website: https://www.vantagedesignworks.com/Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qrOriginal Artwork Concept: Olivia Pawlowski

Episode metadata supplied by the publisher feed · Published Jun 22, 2026

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The hardest part about antidepressants is often not the pill, it is the question you ask yourself before you ever bring it up: “Is this serious enough?” We think that question keeps too many people stuck. We are Ed Delesky (family medicine doctor) and Nicole Aruffo (nurse), and we walk through a clearer test: is depression or anxiety affecting your ability to live your life the way you want to live it? We unpack the stigma that makes mental health feel different from every other medical prob...

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118: When Should You Consider an Antidepressant?

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