EPISODE · Jun 27, 2026 · 27 MIN
1193-原位Perturb-seq解析抑郁症风险基因与转录特征
from 聊聊Sci
这项研究利用体内AAV-Perturb-seq技术系统地分析了重度抑郁症（MDD）相关风险基因的功能。研究人员在小鼠大脑中通过CRISPR/Cas9技术同时敲除了数十个候选风险基因，并利用单细胞测序揭示了这些基因对神经元转录组及功能的影响。通过对比患者数据，科学家们发现了一组与抑郁症转录特征高度吻合的基因簇，这些基因的缺失会导致神经元内的催产素信号通路受损。研究特别以Dennd1a基因作为突破口，证实其在神经元中的表达下调会诱发小鼠产生抑郁样行为。此外，该研究证明通过药理手段修复受损信号通路可有效缓解抑郁表型，为复杂精神疾病的精准医疗和个性化治疗方案提供了关键的机械性见解。References:Zhang L, Kong X, Ma Q, et al. Linking GWAS risk genes to transcriptional features of major depressive disorder via in vivo Perturb-seq[J]. Nature Genetics, 2026: 1-13.前往小宇宙评论区与主播互动
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1193-原位Perturb-seq解析抑郁症风险基因与转录特征
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