1197-Nuclear MAP1B Regulates Neural Stem Cell Fate

Researchers have identified an abundant nuclear pool of cytoskeletal proteins within human and mouse neural stem cells, challenging the traditional view that these components function primarily in the cytoplasm. The study highlights MAP1B, a microtubule-associated protein that shuttles into the nucleus to interact with the BAF chromatin-remodeling complex, thereby influencing gene expression and cell fate. While cytosolic MAP1B supports the transition into neurons, its presence in the nucleus is essential for maintaining neural stem cell identity and ensuring proper brain development. Experiments reveal that reducing MAP1B levels leads to a higher proportion of stem cells and the formation of aberrant neuronal populations that fail to migrate correctly. Furthermore, mutations linked to the brain disorder periventricular heterotopia cause MAP1B to accumulate excessively in the nucleus, disrupting the natural balance of cortical layering. Ultimately, these findings suggest that the subcellular distribution of cytoskeletal proteins is a critical regulator of neurodevelopment and the underlying cause of certain congenital brain diseases.References:Merino F, Miranda L, Kumar A, et al. Nuclear proteome reveals microtubule-associated protein regulating fate and disease[J]. Cell, 2026.前往小宇宙评论区与主播互动