12 11 2023

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C

Baricitinib and β-Cell Function in Patients with New-Onset Type 1 Diabetes

Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes

Mirvetuximab Soravtansine in FRα-Positive, Platinum-Resistant Ovarian Cancer

Journal of  American Medical Association

Sintilimab Plus Chemotherapy for Unresectable Gastric or Gastroesophageal Junction Cancer: The ORIENT-16 Randomized Clinical Trial

Pregnancy After Breast Cancer in Young BRCA Carriers

  Annals of Internal Medicine

Second-Line Chimeric Antigen Receptor T-Cell Therapy in Diffuse Large B-Cell Lymphoma

 Lancet

Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial

  Journal of Clinical Oncology

Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer

  Journal of Hepatology

Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma

  Clinical Gastroenterology

Long-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study

 Blood

Clinical Outcomes in Patients with High-Dose Methotrexate Toxicity Treated with Vs. without Glucarpidase

 Clinical Infectious Diseases

Diagnostic Accuracy of Hospital Antibiograms in Predicting the Risk of Antimicrobial Resistance in Enterobacteriaceae Isolates: A Nationwide Multicenter Evaluation at the Veterans Health Administration

 Journal of Clinical Rheumatology 

Unintentional Monotherapy in Rheumatoid Arthritis Patients Receiving Tofacitinib and Drug Survival Rate of Tofacitinib

  Arthritis and Rheumatology

Poly-refractory Rheumatoid Arthritis: An Uncommon Subset of Difficult to Treat Disease with Distinct Inflammatory and Non-inflammatory Phenotypes

  Circulation

Bag-Valve-Mask Ventilation and Survival From Out-of-Hospital Cardiac Arrest: A Multicenter Study

American College of Cardiology

Long-Term Safety of Inclisiran for Treatment of Hypercholesterolemia

 Journals of the American College of Cardiology

Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials

  Journal of Clinical Endocrinology & Metabolism

Effective GH Replacement With Somapacitan in Children With GHD: REAL4 2-year Results and After Switch From Daily GH

  Neurology:

Association Between Diseases and Symptoms Diagnosed in Primary Care and the Subsequent Specific Risk of Multiple Sclerosis

 Chest

Multiplex Polymerase Chain Reaction Assay to Detect Nasopharyngeal Viruses in Immunocompromised Patients With Acute Respiratory Failure

  The American Journal of Respiratory and Critical Care Medicine

Inflammatory Molecular Endotypes in Bronchiectasis: A European Multicenter Cohort Study

 Clinical and Translational Gastroenterology 

Non-Pure Intestinal Phenotype as an Indicator of Progression in Sporadic Non-ampullary Duodenal Adenomas: A Multicenter Retrospective Cohort Study

  Clinical Journal of American Society of Nephrology

.

Nurse Practitioner Care Compared with Primary Care or Nephrologist Care in Early CKD

  Kidney International reports

Randomized Trial on the Effect of an Oral Spleen Tyrosine Kinase Inhibitor in the Treatment of IgA Nephropathy