12 11 2023

Hi, This Week in Medicine, we will be discussingFirst we will be discussing articles in New England Journal of MedicineSotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12CBaricitinib and β-Cell Function in Patients with New-Onset Type 1 Diabetes Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes Mirvetuximab Soravtansine in FRα-Positive, Platinum-Resistant Ovarian Cancer Journal of  American Medical AssociationSintilimab Plus Chemotherapy for Unresectable Gastric or Gastroesophageal Junction Cancer: The ORIENT-16 Randomized Clinical Trial Pregnancy After Breast Cancer in Young BRCA Carriers  Annals of Internal MedicineSecond-Line Chimeric Antigen Receptor T-Cell Therapy in Diffuse Large B-Cell Lymphoma LancetPembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial  Journal of Clinical OncologyEffect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer  Journal of HepatologyBifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma  Clinical GastroenterologyLong-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study BloodClinical Outcomes in Patients with High-Dose Methotrexate Toxicity Treated with Vs. without Glucarpidase Clinical Infectious DiseasesDiagnostic Accuracy of Hospital Antibiograms in Predicting the Risk of Antimicrobial Resistance in Enterobacteriaceae Isolates: A Nationwide Multicenter Evaluation at the Veterans Health Administration Journal of Clinical Rheumatology Unintentional Monotherapy in Rheumatoid Arthritis Patients Receiving Tofacitinib and Drug Survival Rate of Tofacitinib  Arthritis and RheumatologyPoly-refractory Rheumatoid Arthritis: An Uncommon Subset of Difficult to Treat Disease with Distinct Inflammatory and Non-inflammatory Phenotypes  CirculationBag-Valve-Mask Ventilation and Survival From Out-of-Hospital Cardiac Arrest: A Multicenter Study  American College of CardiologyLong-Term Safety of Inclisiran for Treatment of Hypercholesterolemia Journals of the American College of CardiologySafety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials  Journal of Clinical Endocrinology & MetabolismEffective GH Replacement With Somapacitan in Children With GHD: REAL4 2-year Results and After Switch From Daily GH  Neurology:Association Between Diseases and Symptoms Diagnosed in Primary Care and the Subsequent Specific Risk of Multiple Sclerosis ChestMultiplex Polymerase Chain Reaction Assay to Detect Nasopharyngeal Viruses in Immunocompromised Patients With Acute Respiratory Failure  The American Journal of Respiratory and Critical Care MedicineInflammatory Molecular Endotypes in Bronchiectasis: A European Multicenter Cohort Study Clinical and Translational Gastroenterology Non-Pure Intestinal Phenotype as an Indicator of Progression in Sporadic Non-ampullary Duodenal Adenomas: A Multicenter Retrospective Cohort Study  Clinical Journal of American Society of Nephrology.Nurse Practitioner Care Compared with Primary Care or Nephrologist Care in Early CKD  Kidney International reportsRandomized Trial on the Effect of an Oral Spleen Tyrosine Kinase Inhibitor in the Treatment of IgA Nephropathy