12 18 2023

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

Recombinant or Standard-Dose Influenza Vaccine in Adults under 65 Years of Age

Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma

 Annals of Internal Medicine

Development and Validation of the CANHEART Population-Based Laboratory Prediction Models for Atherosclerotic Cardiovascular Disease

 Nature Medicine

Inhibition of the KCa2 potassium channel in atrial fibrillation: a randomized phase 2 trial

  Lancet

Pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in Canada, Italy, and France: a phase 3, open-label, randomised controlled trial

 Journal of Clinical Oncology

High-Dose Methotrexate as CNS Prophylaxis in High-Risk Aggressive B-Cell Lymphoma

 journal of Hepatology

Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma

Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US

 Clinical Gastroenterology

Reflux Symptoms Increase Following Sleeve Gastrectomy Despite Triage of Symptomatic Patients to Roux-en-Y Gastric Bypass

Safety and Efficacy of Endoscopic Full Thickness Resection of Upper Gastrointestinal Lesions Using a Full Thickness Resection Device: A Systematic Review and Meta-analysis

  Clinical Infectious Diseases

Patient Characteristics, Microbiology, and Mortality of Infective Endocarditis After Transcatheter Aortic Valve Implantation

Temporal Trends in Hepatitis C–Related Hospitalizations, United States, 2000–2019

  Journal of Clinical Rheumatology 

Unintentional Monotherapy in Rheumatoid Arthritis Patients Receiving Tofacitinib and Drug Survival Rate of Tofacitinib

 Arthritis and Rheumatology

A Randomized, Double-Blind, Sham-Controlled, Clinical Trial of Auricular Vagus Nerve Stimulation for the Treatment of Active Rheumatoid Arthritis

  Circulation

Rivaroxaban Plus Aspirin Versus Aspirin Alone After Endovascular Revascularization for Symptomatic PAD: Insights From VOYAGER PAD

American College of Cardiology

Predictors of Outcomes in Mild Pulmonary Hypertension 

Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials

 Journal of Clinical Endocrinology & Metabolism

DI/cle, a Measure Consisting of Insulin Sensitivity, Secretion, and Clearance, Captures Diabetic States

Tissue Glucocorticoid Metabolism in Adrenal Insufficiency: A Prospective Study of Dual-release Hydrocortisone Therapy

 Neurology:

Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke

 Chest

CT Scan Differences of Pulmonary TB According to Presence of Pleural Effusion

  The American Journal of Respiratory and Critical Care Medicine

Impact of Undiagnosed Chronic Obstructive Pulmonary Disease and Asthma on Symptoms, Quality of Life, Healthcare Use, and Work Productivity

  Clinical Gastroenterology AND Hepatology

Long-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study

  Clinical Journal of American Society of Nephrology

.

Cystatin C–Based eGFR Changes during Gender-Affirming Hormone Therapy in Transgender Individuals

  Kidney International reports

Sex/Gender-Based Disparities in Early Transplant Access by Attributed Cause of Kidney Disease–Evidence from a Multiregional Cohort in the Southeast United States