12 2 2024

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer

Fractional Doses of Pneumococcal Conjugate Vaccine — A Noninferiority Trial

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer

 Journal of  American Medical Association

Association of Severe Maternal Morbidity With Subsequent Birth

Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery

Transcatheter Edge-to-Edge Repair for Severe Isolated Tricuspid Regurgitation

The Tri.Fr Randomized Clinical Trial

  Annals of Internal Medicine

Association of Work Control With Burnout and Career Intentions Among U.S. Physicians: A Multi-Institution Stud

  British Medical Journal

Contemporary menopausal hormone therapy and risk of cardiovascular disease

 Lancet

Balloon guide catheters for endovascular thrombectomy in patients with acute ischaemic stroke due to large-vessel occlusion in China (PROTECT-MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial

 Cancer Journal for Clinicians

A phase 2 study of a brachyury-targeting vaccine in combination with radiation therapy for the treatment of advanced chordoma

 Journal of Clinical Oncology

Prospective Study of Supplemental Screening With Contrast-Enhanced Mammography in Women With Elevated Risk of Breast Cancer: Results of the Prevalence Round

 journal of Hepatology

Efficacy, tolerability and pharmacokinetics of survodutide, a glucagon/glucagon-like peptide-1 receptor dual agonist, in cirrhosis

Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma

 Gastroenterology

Gut Pathobiont–Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis–Associated Inflammatory Bowel Disease

 Clinical Gastroenterology

 Updated Reference Intervals for Alanine Aminotransferase in a Metabolically and Histologically Normal Population

   Clinical Infectious Diseases

The Use of Long-term Antibiotics for Suppression of Bacterial Infections 

 Rheumatology 

Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic

   Journal of Clinical Rheumatology 

 Circulation

ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension

  Journals of the American College of Cardiology

Recaticimab Monotherapy for Nonfamilial Hypercholesterolemia and Mixed Hyperlipemia: The Phase 3 REMAIN-1 Randomized Trial

  JAMA Cardiology

Routine Protamine Administration for Bleeding in Transcatheter Aortic Valve ImplantationThe ACE-PROTAVI Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study 

 Diabetes care

Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study

   Neurology

SGLT2 Inhibitor Use and Risk of Dementia and Parkinson Disease Among Patients With Type 2 Diabetes

 Chest

Rethinking Blood Eosinophils for Assessing Inhaled Corticosteroids Response in COPD

  The American Journal of Respiratory and Critical Care Medicine

Preacinar Arterial Dilation Mediates Outcomes of Quantitative Interstitial Abnormalities in the COPDGene Study

 Clinical Journal of American Society of Nephrology

Acute Myocardial Infarction and Chronic Kidney Disease: A Nationwide Cohort Study on Management and Outcomes from 2010 to 2022

 Kidney International reports

Randomized Trial of Patiromer on Efficacy to Reduce Episodic Hyperkalemia in Patients with ESKD Treated With Hemodialysis