1216-肠道微生物组与癌症免疫检查点阻断治疗的代谢控制

该综述探讨了肠道微生物群在癌症免疫检查点阻断（ICB）疗法中的核心调节作用。研究表明，肠道菌群的多样性以及特定的微生物代谢产物（如短链脂肪酸）能显著增强抗肿瘤免疫力，从而提升治疗效果。此外，文章阐述了饮食结构（特别是高纤维与高脂肪饮食）如何通过改变肠道生态来干预免疫反应。作者还分析了微生物在免疫相关不良反应中的诱发机制，并指出了利用菌群移植优化临床疗法的潜力。总之，肠道环境与宿主免疫系统之间的复杂通信回路是决定癌症免疫治疗成败的关键。References:Gladstone JL, Sonnenberg GF. Gut microbiota and metabolic control of immune checkpoint blockade in cancer. Cell Metab. 2026 May 25:S1550-4131(26)00156-7. doi: 10.1016/j.cmet.2026.04.018. Epub ahead of print. Erratum in: Cell Metab. 2026 Jun 10:S1550-4131(26)00234-2. doi: 10.1016/j.cmet.2026.06.008. PMID: 42184832; PMCID: PMC13267733.前往小宇宙评论区与主播互动

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1216-肠道微生物组与癌症免疫检查点阻断治疗的代谢控制

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